Garnipril 5

Description

Garnipril 5 is a class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. Garnipril 5 is an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Garnipril 5 , is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies and to prevent stroke, myocardial infarction and cardiac death in high-risk patients. Garnipril 5 competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin-I to angiotensin-II. This prevents the potent vasoconstrictive actions of angiotensin-II resulting in vasodilation. Garnipril 5 also decreases angiotensin-II induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.